Endocrine Abstracts

Background: Gastric reduction duodenal switch involves restrictive and mal-absorptive aspect, removing approximately 70% of stomach and most of the duodenum. Surgical alteration leading to malabsorption of macronutrients is achieved with varying results of weight loss but resulting nutritional side effects are under-recognised. Issues in nutritional complication leading to neurological complications like peripheral neuropathy are increasingly recognised. We discuss a case of s...

Background: Bariatric surgery has contributed to a large spectrum of presentations of hypoglycaemia. Dumping syndrome caused by food reaching the duodenum rapidly is associated with abdominal pain, bloating and diarrhoea as well as vasogenic symptoms of tachycardia and flushing. Hypoglycaemia may occur as a late sign of dumping 1–3 hours after a meal. In contrast, post-gastric bypass reactive hypoglycaemia is thought to result from discordance between blood glucose circul...

Aims: In 2005 we defined a specific reference range for TSH in our pregnant population. We have assessed whether this has resulted in changed management of treated hypothyroidism in pregnant.Methods: The management of 73 mothers (Group 1) between January 2000 and July 2005 was compared to that of 67 mothers (Group 2) between August 2005 and December 2009. The upper limit of normal for TSH was 4.5 mU/l till July 2005; the specific TSH range defined for pr...

Context: Parathyroid carcinoma is a very rare malignancy. It arises as a separate structure rather than from a pre-existing parathyroid adenoma. It may be difficult to differentiate it from parathyroid adenoma based on histology. When evaluating primary hyperparathyroidism clinical correlation should be taken into account. Clinical features of parathyroid carcinoma may include male gender, palpable neck nodule and higher parathyroid hormone and serum calcium levels associated ...

In October 2006 a 53-year-old, non-smoking woman presented with ectopic Cushings from a small cell, undifferentiated carcinoma (Grade 3 neuroendocrine) from a 10 mm tumour at the left lung hilum (Cortisol: 09:00 a.m. 720 nmol/l; 24.00 mm 742 nmol/l. ACTH 114 ng/l). Four years before she had sustained a myocardial infarction, with atrial fibrillation, and was found to have Graves’ disease, being treated initially with carbimazole then radioactive iodine, becoming hypothyro...